Abstract: Civil Engineers play a significant role in the sustainability and safety of existing nuclear power plants as well as in the design and construction of advanced reactors. Structural safety assessments are key to ensuring resiliency of not only the concrete containment and other buildings but also the mechanical and electrical systems. Engineers continue to work on improving the resiliency of these large complex systems against natural hazards such as earthquakes, hurricanes, and floods. In addition, the plant systems exhibit fairly significant thermal and vibration fatigue, flow assisted corrosion, and ageing related degradation during their lifetimes. All of these aspects require innovative solutions based on the concepts of structural mechanics, innovative materials, geotechnical engineering, fluid-structure interactions, computational fluid dynamics, non-destructive testing, health monitoring, etc. In recent decades, nuclear industry has led the development of risk-informed design and decision making approaches for operational as well as licensing decisions. This requires appropriate characterization of uncertainties in our understanding of physical phenomenon and in our models that are used to represent them. Some of the most recent research has focused on developing risk-informed methodologies for verification and validation of advanced simulation tools and on developing Artificial Intelligence (AI) based solutions to assist with the design and construction of advanced reactors which are truly being designed as cyber-physical systems. Nuclear industry has also struggled with managing the cost and schedules of constructing new large-sized plants throughout the developed countries. Recent research aims to address this aspect through an integrated virtual design and construction platform that uses the power of digital and thermal imaging. Presently, more than a quarter of North Carolina’s electricity comes from nuclear and at national level this largest source of carbon-free electricity generation contributes about 20% to our consumption.